Error profile heatmap

Left panel shows root mean squared error (RMSE) of each outlier sample’s mutation spectrum. Right panel shows the fold-difference in contribution per subtype for each outlier. Fold-differences are calculated relative to the mean contribution of that subtype across all samples.

##  [1] "#E495A5" "#E495A5" "#E495A5" "#E495A5" "#E495A5" "#E495A5" "#E495A5"
##  [8] "#E495A5" "#E495A5" "#E495A5" "#86B875" "#86B875" "#86B875" "#86B875"
## [15] "#86B875" "#86B875" "#7DB0DD" "#7DB0DD" "#7DB0DD" "#7DB0DD" "#7DB0DD"
## [22] "#7DB0DD" "#7DB0DD" "#7DB0DD" "#7DB0DD"

Combined mutation spectrum

These plots shows the total number of observations in each subtype, combined across all samples

All samples

##  [1] "#E495A5" "#E495A5" "#E495A5" "#E495A5" "#E495A5" "#E495A5" "#E495A5"
##  [8] "#E495A5" "#E495A5" "#E495A5" "#86B875" "#86B875" "#86B875" "#86B875"
## [15] "#86B875" "#86B875" "#7DB0DD" "#7DB0DD" "#7DB0DD" "#7DB0DD" "#7DB0DD"
## [22] "#7DB0DD" "#7DB0DD" "#7DB0DD" "#7DB0DD"

Signature loadings (H matrix)

Describes how each mutation subtype is loaded into the r signatures

## # A tibble: 3 x 4
##   rowname         S1         S2         S3
##     <chr>      <dbl>      <dbl>      <dbl>
## 1      S1         NA -0.4194753 -0.1991260
## 2      S2 -0.4194753         NA -0.8060593
## 3      S3 -0.1991260 -0.8060593         NA

Signature contributions per sample (W matrix)

Proportion each signature contributes to the mutation spectrum in each individual sample